EZH2 is a key component of hepatoblastoma tumor cell growth.

Kathryn GlaserEmily J SchepersHarrison M ZwolshenCharissa M LakeNikolai A TimchenkoRebekah A KarnsStefano CairoJames I GellerGregory M TiaoAlexander J Bondoc

Published in: Pediatric blood & cancer (2023)

EZH2 overexpression promotes HB cell proliferation, with both canonical and noncanonical function detected. However, because EZH2 directly interacts with β-catenin in human tumors and EZH2 overexpression is not equal to SUZ12, it seems that a noncanonical mechanism is contributing to HB pathogenesis. Further mechanistic studies are necessary to elucidate potential pathogenic downstream mechanisms and translational potential of EZH2 inhibitors for the treatment of HB.

Keyphrases

cell proliferation
long noncoding rna
long non coding rna
endothelial cells
cell cycle
transcription factor
epithelial mesenchymal transition
human health
risk assessment
induced pluripotent stem cells
case control
combination therapy