Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey.
Hyemin JeongSun-Young BaekSeon-Woo KimEun-Jung ParkHyungjin KimJaejoon LeeChan-Hong JeonPublished in: Medicina (Kaunas, Lithuania) (2021)
Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of 3177 (weighted n = 19,770,902) participants aged 40 years or older were selected from the 2016 Korean National Health and Nutrition Examination Survey and included. Results: Female participants with hyperuricemia were older than participants with normouricemia. Body mass index (BMI), mean arterial pressure (MAP), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) were significantly associated with UA levels in both males and females. Hyperuricemia and increase in UA quartile were significantly associated with decreased forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in females after adjustment for age, income, region, education, marital status, alcohol consumption, smoking, BMI, MAP, HbA1c, and eGFR. There was no significant association between UA levels and lung function in males. After additional adjustment for respiratory disease including pulmonary tuberculosis, asthma, and lung cancer, the association between hyperuricemia and decreased FEV1 and FVC in females was revealed. Conclusions: Hyperuricemia was associated with decreased FVE1 and FVC in the female general population.
Keyphrases
- uric acid
- lung function
- body mass index
- metabolic syndrome
- pulmonary tuberculosis
- alcohol consumption
- physical activity
- small cell lung cancer
- chronic obstructive pulmonary disease
- air pollution
- epidermal growth factor receptor
- cystic fibrosis
- mental health
- weight gain
- healthcare
- tyrosine kinase
- mycobacterium tuberculosis
- community dwelling
- middle aged
- magnetic resonance
- smoking cessation
- electronic health record
- high density
- computed tomography
- single cell
- magnetic resonance imaging
- acute respiratory distress syndrome
- intensive care unit
- quality improvement
- mechanical ventilation
- contrast enhanced
- data analysis
- red blood cell