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In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe.

Limin ShiChenxu YanYiyu MaTing WangZhi-Qian GuoWei-Hong Zhu
Published in: Chemical communications (Cambridge, England) (2019)
Herein, we developed a dual-channel and light-up near-infrared fluorescent probe for ratiometric sensing of β-galactosidase (β-gal) activity. The well-designed probe, which shows ratiometric optical response with a significant red-shift (from 575 nm to 730 nm), was successfully applied to detect endogenous β-gal activity in SKOV-3 cells and tumor-bearing mice.
Keyphrases
  • fluorescent probe
  • living cells
  • photodynamic therapy
  • induced apoptosis
  • type diabetes
  • oxidative stress
  • high resolution
  • mass spectrometry
  • insulin resistance
  • high speed
  • cell death
  • wild type