Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome.

Alexandra J Roth-SchulzeMegan A S PennoKatrina M NguiHelena OakeyEsther Bandala-SanchezAlannah D SmithTheo R AllnuttRebecca L ThomsonPeter J VuillerminMaria E CraigWilliam D RawlinsonElizabeth A DavisMark HarrisGeorgia SoldatosPeter G ColmanJohn M WentworthAveni HaynesSimon C BarryRichard O SinnottGrant MorahanNaiara G BediagaGordon K SmythAnthony T PapenfussJennifer J CouperLeonard C Harrisonnull null

Published in: Microbiome (2021)

Women with T1D exhibit a shift towards a more pro-inflammatory gut microbiome during pregnancy, associated with evidence of intestinal inflammation. These changes could contribute to the increased risk of pregnancy complications in women with T1D and are potentially modifiable by dietary means. Video abstract.

Keyphrases

type diabetes
preterm birth
pregnancy outcomes
oxidative stress
cardiovascular disease
risk factors
insulin resistance
metabolic syndrome
adipose tissue