Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes.

Nans FlorensRajesh K KasamValeria Rudman-MelnickSuh-Chin LinVikram PrasadJeffery D Molkentin

Published in: Circulation (2023)

These results indicate that IL-33 released from the kidney during AKI underlies cardiorenal syndrome by directly signaling to cardiac myocytes, suggesting that antagonism of IL-33/ST2 axis would be cardioprotective in patients with kidney disease.

Keyphrases

acute kidney injury
cardiac surgery
heart failure
left ventricular
atrial fibrillation
high glucose