Salvage therapies of autoimmune hepatitis limit proinflammatory immune cells while sparing regulatory T cells.
Finn C DerbenHenriette YttingBjörn HartlebenHeike BantelHeiner WedemeyerGro L WillemoeElmar JaeckelRichard TaubertPublished in: Hepatology communications (2023)
Non-SOC in AIH partially controls intrahepatic inflammation by limiting the hepatic infiltration of total T and B cells as the main drivers of inflammation without further decreasing intrahepatic Treg. A negative effect of calcineurin inhibitor and a positive effect of mammalian target of rapamycin inhibitors on the number of intrahepatic Treg was not observed.