Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis.

Agathe LeblondSonia PezetAnne CauvetClaudine CasasJulie Pires Da SilvaRoxane HervéGaelle ClavelSébastien DumasSylvia Cohen-KaminskyNatacha BessisLuca SemeranoChristophe LemaireYannick AllanoreJerome Avouac

Published in: Annals of the rheumatic diseases (2020)

These results support a role of SIRT1 in RA and may have therapeutic implications, since targeting angiogenesis, and especially SIRT1, might be used as a complementary therapeutic approach in RA.

Keyphrases

rheumatoid arthritis
endothelial cells
vascular endothelial growth factor
oxidative stress
disease activity
ischemia reperfusion injury
ankylosing spondylitis
wound healing
systemic lupus erythematosus
drug delivery
systemic sclerosis