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Advances in the Asymmetric Synthesis of BINOL Derivatives.

Everton Machado da SilvaHérika Danielle Almeida VidalMarcelo Augusto Pereira JanuárioArlene Gonçalves Corrêa
Published in: Molecules (Basel, Switzerland) (2022)
BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed.
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