Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis.
Xudong WangTongzhou LiangYuanxin ZhuJincheng QiuXianjian QiuChengjie LianBo GaoYan PengAnjing LiangHang ZhouXiaoming YangZhiheng LiaoYongyong LiCaixia XuPeiqiang SuDongsheng HuangPublished in: Molecular medicine (Cambridge, Mass.) (2019)
Melatonin can alleviate bone loss in RA-induced OP model mice, repair the trabecular microstructure, and promote bone formation. These effects may be related to reducing oxidation levels in vivo and vitro through the ERK/SMAD and NF-κB pathways.
Keyphrases
- bone loss
- bone mineral density
- signaling pathway
- high glucose
- diabetic rats
- high fat diet induced
- postmenopausal women
- pi k akt
- rheumatoid arthritis
- drug induced
- oxidative stress
- cell proliferation
- type diabetes
- multiple sclerosis
- body composition
- insulin resistance
- adipose tissue
- nitric oxide
- inflammatory response
- wild type
- interstitial lung disease