Evolving rifampicin and isoniazid mono-resistance in a high multidrug-resistant and extensively drug-resistant tuberculosis region: a retrospective data analysis.
Nomonde Ritta MvelaseYusentha BalakrishnaKeeren LutchminarainKoleka MlisanaPublished in: BMJ open (2019)
Our findings show increasing RIF mono-resistance (RMR) and a substantial amount of IMR. This highlights a need for an initial test that detects resistance to both these drugs so as to avoid using RIF monotherapy during continuous phase of treatment in patients with IMR. Furthermore, addition of INH will benefit patients with RMR. Although DR-TB is widespread, HIV and migration influence its distribution; therefore, TB control strategies should include interventions that target these aspects.
Keyphrases
- multidrug resistant
- drug resistant
- mycobacterium tuberculosis
- pulmonary tuberculosis
- data analysis
- acinetobacter baumannii
- gram negative
- klebsiella pneumoniae
- combination therapy
- antiretroviral therapy
- hiv aids
- physical activity
- human immunodeficiency virus
- hiv infected
- hepatitis c virus
- escherichia coli
- open label