Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults.
Jessica D SchulteRobin A BuerkiSarah LapointeAnnette M MolinaroYalan ZhangJavier E Villanueva-MeyerArie PerryJoanna J PhillipsTarik TihanAndrew W BollenMelike PekmezciNicholas ButowskiNancy Ann Oberheim BushJennie W TaylorSusan M ChangPhilip TheodosopoulosManish K AghiShawn L Hervey-JumperMitchell S BergerDavid A SolomonJennifer L ClarkePublished in: Neuro-oncology advances (2020)
Together, these findings indicate that H3 K27M-mutant DMG represents a heterogeneous disease with regard to outcomes, sites of origin, and molecular pathogenesis in adults versus children.