Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose-Insulin Homeostasis in Youth: The Exploring Perinatal Outcomes Among Children (EPOCH) Study.

Maggie A StanislawskiElizabeth LitkowskiSridharan RaghavenKylie K HarrallJessica ShawDeborah H GlueckEthan M LangeDana M DabeleaLeslie A Lange

Published in: Diabetes care (2021)

Our results suggest that T2D genetic risk factors established in adults are relevant to glucose-insulin homeostasis in youth and that maintaining a healthy weight may be particularly important for youth with high genetic risk of T2D.

Keyphrases

type diabetes
physical activity
genome wide
young adults
glycemic control
mental health
risk factors
blood glucose
copy number
body mass index
dna methylation
insulin resistance
gene expression
metabolic syndrome
skeletal muscle