Co-Packaged PARP inhibitor and photosensitizer for targeted photo-chemotherapy of 3D ovarian cancer spheroids.

Aaron SorrinAnika DasguptaKathryn McNaughtonCarla Arnau Del ValleKeri ZhouCindy LiuDana M RoqueHuang-Chiao Huang

Published in: Cell & bioscience (2024)

This study provides key insights into manufacturing parameters for PARPi-loaded nanoparticles, as well as the potential role of PDT-based combination therapies in the context of acquired drug resistance.

Keyphrases

photodynamic therapy
cancer therapy
drug delivery
dna damage
dna repair
locally advanced
radiation therapy
oxidative stress
human health
wound healing
climate change
chemotherapy induced