Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging.
Hany AriffinMohamad Shafiq AzananSayyidatul Syahirah Abd GhafarLixian OhKee Hie LauTharshanadhevasheri ThirunavakarasuAtiqah SedanKamariah IbrahimAdelyne ChanTong Foh ChinFong Fong LiewShareni JeyamoganErda Syerena RosliRashidah BaharudinTsiao Yi YapRoderick SkinnerSu Han LumPierre HainautPublished in: Cancer (2017)
Asymptomatic young adult survivors of childhood ALL demonstrate a biologic profile of chronic inflammation and telomere attrition, consistent with an early onset of cellular processes that drive accelerated aging. These processes may explain the premature development of age-related chronic conditions in childhood cancer survivors. Understanding their molecular basis may facilitate targeted interventions to disrupt the accelerated aging process and its long-term impact on overall health. Cancer 2017;123:4207-4214. © 2017 American Cancer Society.
Keyphrases
- childhood cancer
- young adults
- early onset
- acute lymphoblastic leukemia
- oxidative stress
- papillary thyroid
- late onset
- healthcare
- public health
- rheumatoid arthritis
- early life
- physical activity
- mental health
- squamous cell carcinoma
- cancer therapy
- drug delivery
- allogeneic hematopoietic stem cell transplantation
- climate change
- health information
- human health