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In vitro synergy between sodium deoxycholate and furazolidone against enterobacteria.

Vuong Van Hung LeCatrina OliveraJulian SpagnuoloIeuan G DaviesJasna Rakonjac
Published in: BMC microbiology (2020)
This study is to our knowledge the first report of nitrofuran-deoxycholate synergy against Gram-negative bacteria, offering potential applications in antimicrobial therapeutics. The mechanism of DOC-FZ synergy involves FZ-mediated inhibition of TolC-associated efflux pumps that normally remove DOC from bacterial cells. One possible route contributing to that effect is via FZ-mediated nitric oxide production.
Keyphrases
  • nitric oxide
  • induced apoptosis
  • healthcare
  • cell cycle arrest
  • staphylococcus aureus
  • small molecule
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death