Phase 3 Trial of Cabozantinib to Treat Advanced Neuroendocrine Tumors.
Jennifer A ChanSusan GeyerTyler ZemlaMichael V KnoppSpencer BehrSydney PulsipherFang-Shu OuAmylou C DueckJared AcobaArdaman ShergillEdward M WolinThorvardur R HalfdanarsonBhavana KondaNikolaos A TrikalinosBernard TawfikNitya RajShagufta ShaheenNamrata VijayvergiaArvind DasariJonathan R StrosbergElise C KohnMatthew H KulkeEileen M O'ReillyJeffrey A MeyerhardtPublished in: The New England journal of medicine (2024)
Cabozantinib, as compared with placebo, significantly improved progression-free survival in patients with previously treated, progressive advanced extrapancreatic or pancreatic neuroendocrine tumors. Adverse events were consistent with the known safety profile of cabozantinib. (Funded by the National Cancer Institute and others; CABINET ClinicalTrials.gov number, NCT03375320.).