The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease.

Masahiro EriguchiEllen A BernsteinLuciana C VeirasZakir KhanDuo Yao CaoSebastien FuchsAlicia A McDonoughJorge E ToblliRomer A Gonzalez-VillalobosKenneth E BernsteinJorge F Giani

Published in: Journal of the American Society of Nephrology : JASN (2018)

These data indicate that increasing AcSDKP by blocking the ACE N-domain facilitates sodium excretion and ameliorates diabetic kidney disease independent of intrarenal angiotensin II regulation.

Keyphrases

angiotensin ii
angiotensin converting enzyme
vascular smooth muscle cells
type diabetes
wound healing
oxidative stress
electronic health record
big data
machine learning
deep learning