Ferulic acid produces neuroprotection against radiation-induced neuroinflammation by affecting NLRP3 inflammasome activation.

Guifang LiuYao NieCongshu HuangGuihua ZhuXuemei ZhangChangkun HuZhihui LiYue Gao Zeng-Chun Ma

Published in: International journal of radiation biology (2022)

This study established that FA targeting the NLRP3 inflammasome has a neuroprotective effect against radiation-induced nerve damage, implying that FA might have some potential in the treatment of radiation-induced cognitive impairment.

Keyphrases

radiation induced
nlrp inflammasome
cognitive impairment
radiation therapy
cerebral ischemia
oxidative stress
traumatic brain injury
brain injury
lipopolysaccharide induced
blood brain barrier
cancer therapy
risk assessment
human health
inflammatory response
replacement therapy