Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster.

Navid J Ayon Cody E EarpRaveena GuptaFatma A ButunAshley E ClementsAlexa G LeeDavid DainkoMatthew T RobeyManead Khin Lina Mardiana Alexandra Longcake Manuel Rangel-Grimaldo Michael John Hall Michael Richard Probert Joanna E Burdette Nancy P Keller Huzefa A Raja Nicholas H Oberliels Michael P Snyder Lindsay K Caesar

Published in: Metabolomics : Official journal of the Metabolomic Society (2024)

This work demonstrates how the incorporation of biochemometrics as a third dimension into the metabologenomics workflow can identify bioactive metabolites and link them to their biosynthetic machinery.

Keyphrases

genome wide
ms ms
copy number
dna methylation
molecular docking
electronic health record
cell wall