18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.

Richard M TsaiAlexandre BejaninOrit Lesman-SegevRenaud LaJoieAdrienne VisaniViktoriya BourakovaJames P O'NeilMustafa JanabiSuzanne BakerSuzee E LeeDavid C PerryLynn BajorekAnna KarydasSalvatore SpinaLea T GrinbergWilliam W SeeleyEliana M RamosGiovanni CoppolaMaria Luisa Gorno-TempiniBruce L MillerHoward J RosenWilliam JagustAdam L BoxerGil D Rabinovici

Published in: Alzheimer's research & therapy (2019)

18F-flortaucipir in patients with FTD and predicted tauopathy or TDP-43 pathology demonstrated limited sensitivity and specificity. Further postmortem pathological confirmation and development of FTD tau-specific ligands are needed.

Keyphrases

cerebrospinal fluid
computed tomography
pet ct
positron emission tomography
amyotrophic lateral sclerosis