Photoredox/Copper Dual-Catalyzed Phosphorothiolation of Propargylic Derivatives for the Switchable Synthesis of S -Alkyl, S -Vinyl and S -Allenyl Phosphorothioates.

Herein, we report a photoredox/copper dual-catalyzed selective phosphorothiolation of propargylic derivatives from easily accessible [P(O)SH] compounds. This reaction provides a general, mild and versatile procedure to synthesize a variety of synthetically useful S -alkyl, S -vinyl and S -allenyl phosphorothioates selectively from the same set of simple starting materials.