Takes one to B1a: Dismantling the origin of mantle cell lymphoma.

Published in: The Journal of experimental medicine (2021)

Therapeutic discovery for mantle cell lymphoma (MCL) has been hindered by a lack of preclinical mouse models that recapitulate human disease. In this issue, Pieters and colleagues (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202280) establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL.

Keyphrases

mouse model
cell cycle arrest
induced apoptosis
cell therapy
endothelial cells
single cell
small molecule
cell proliferation
cell death
induced pluripotent stem cells
high throughput
transcription factor
pi k akt
signaling pathway
oxidative stress
mesenchymal stem cells
bone marrow