Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury.
Jian ZhangYingying XieJushuai MaKaiqiang LiuYunshu DingYong LiXiaoyun JiaoXilei XieXu WangBo TangPublished in: Chemical communications (Cambridge, England) (2023)
Two fluorescent probes (QM-S and QM-Se) featuring AIE properties were developed. The increased intracellular hypobromous acid (HOBr) in cardiomyocytes during MIRI was revealed with these probes. It was also observed that MIRI might be alleviated by combating oxidative stress, as well as inhibiting inflammation and ferroptosis, which could mediate oxidative stress.
Keyphrases
- living cells
- oxidative stress
- ischemia reperfusion injury
- fluorescent probe
- single molecule
- diabetic rats
- dna damage
- induced apoptosis
- left ventricular
- cell death
- small molecule
- single cell
- reactive oxygen species
- fluorescence imaging
- quantum dots
- heart failure
- endothelial cells
- atrial fibrillation
- heat shock protein