Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti-inflammatory molecule PH46A.
Kit ChanNeil H FrankishTao ZhangAbdulilah EceAoife CannonJacintha N O'SullivanHelen SheridanPublished in: The Journal of pharmacy and pharmacology (2020)
The observed profile of cytokine modulation (IL-6/ TNF-α, IL-8) and inhibition of release of NO and 5-LOX may contribute to the in vivo effects demonstrated by indane dimers and PH46A (1) in murine models of colitis.