Half of rifampicin-resistant Mycobacterium tuberculosis complex isolated from tuberculosis patients in Sub-Saharan Africa have concomitant resistance to pyrazinamide.
Jean Claude Semuto NgabonzizaAwa Ba DialloElisa TaglianiBassirou DiarraAbalo Essosimna KadangaAntieme Combo George TogoAliou ThiamWillem Bram de RijkRiccardo AlagnaSabine HouetoFatoumata BaAnoumou Yaotsè DagnraEmil IvanDissou AffolabiValérie SchwoebelArnaud TrebucqBouke Catherine de JongLeen RigoutsGéraldine Daneaunull nullPublished in: PloS one (2017)
Similar to findings in other regions, more than half of the patients having RR-TB in West and Central Africa present concomitant resistance to PZA. Further investigations are needed to understand the relation between resistance to PZA and resistance to fluoroquinolones, and whether continued use of PZA in the face of PZA resistance provides clinical benefit to the patients.