Alteration of autophagy-related protein 5 (ATG5) levels and Atg5 gene expression in diabetes mellitus with and without complications.

Remah YassinHagar TadmorEvgeny FarberAnas IgbariyeAida Armaly-NakhoulInbal DahanNakhoul FaridNakhoul Nakhoul

Published in: Diabetes & vascular disease research (2022)

We conclude that ATG5, as well as LC3B, are down regulated in diabetic patients with or without complications. This diminution contributes to deficiencies in the autophagy process.

Keyphrases

gene expression
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
risk factors
dna methylation
type diabetes
transcription factor
simultaneous determination
mass spectrometry
wound healing
metabolic syndrome
glycemic control
insulin resistance
high resolution mass spectrometry