Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus.
Dominik K E BeyerAnnika MattukatNadja FreundPublished in: International journal of bipolar disorders (2021)
Behavioral and neurobiological findings support the association of manipulation of the D1R in the mPFC on anxiety and inflammation in the hippocampus. In addition, by confirming changes in the inflammatory state, the proposed animal model for bipolar disorder has been further validated.
Keyphrases
- bipolar disorder
- cerebral ischemia
- oxidative stress
- cognitive impairment
- sleep quality
- major depressive disorder
- prefrontal cortex
- traumatic brain injury
- working memory
- lipopolysaccharide induced
- functional connectivity
- subarachnoid hemorrhage
- lps induced
- transcranial magnetic stimulation
- depressive symptoms
- brain injury
- inflammatory response
- binding protein