Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions.

Matthias KästleCamilla MertenRoland HartigThilo KaehneArdiyanto Liaunardy-JopeaceNadine M WoessnerWolfgang W SchamelJohn JamesSusana MinguetLuca SimeoniBurkhart Schraven

Published in: Cell communication and signaling : CCS (2020)

Our data change the current view on the function of Y192 and suggest that Y192 also regulates Lck activity in a manner independent of Y505 phosphorylation. Video Abstract.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
electronic health record
binding protein
protein kinase
nk cells
small molecule