Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer.
Mitsuro KandaDai ShimizuKoichi SawakiShunsuke NakamuraShinichi UmedaTakashi MiwaHaruyoshi TanakaChie TanakaMasamichi HayashiYohei IguchiSuguru YamadaMasahisa KatsunoYasuhiro KoderaPublished in: Molecular cancer (2020)
NPTXR plays an essential role in controlling the malignant behavior of GC cells in vitro and in vivo. NPTXR-targeting Abs may thus have utility as novel diagnostic tools and/or treatment modalities for GC.