Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer.

Mitsuro KandaDai ShimizuKoichi SawakiShunsuke NakamuraShinichi UmedaTakashi MiwaHaruyoshi TanakaChie TanakaMasamichi HayashiYohei IguchiSuguru YamadaMasahisa KatsunoYasuhiro Kodera

Published in: Molecular cancer (2020)

NPTXR plays an essential role in controlling the malignant behavior of GC cells in vitro and in vivo. NPTXR-targeting Abs may thus have utility as novel diagnostic tools and/or treatment modalities for GC.

Keyphrases

monoclonal antibody
induced apoptosis
cancer therapy
cell cycle arrest

gas chromatography
cell death
mass spectrometry

signaling pathway
combination therapy
binding protein

subarachnoid hemorrhage
simultaneous determination
liquid chromatography