Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons.
Pei-Yi SunHua-Guo LiQian-Yue XuZhen ZhangJia-Wen ChenYi-Hang ShenXin QiJian-Fei LuYi-Dong TanXiao-Xiao WangChun-Xiao LiMeng-Ying YangYu-Zhi MaYing LuTian-Le XuJin-Wen ShenWei-Guang LiYi-Feng GuoZhi-Rong YaoPublished in: British journal of pharmacology (2022)
sensory neurons play a critical role in pathogenesis of AD and lidocaine is a potential anti-inflammatory and anti-pruritic agent for AD. A precise and dissociable pattern for sensory neuronal modulation of skin inflammation and itch contributes to further understanding of pathogenesis in AD.