Vibrational spectroscopy identifies myocardial chemical modifications in heart failure with preserved ejection fraction.

Leonardo PioppiReza ParvanAlan SamrendGustavo Jose Justo SilvaMarco PaolantoniPaola SassiAlessandro Cataliotti

Published in: Journal of translational medicine (2023)

By the analyses of tissues and tissue prints, FTIR and Raman techniques were shown to be highly sensitive and selective in detecting changes in the chemistry of the heart in experimental HFpEF and its related comorbidities. Vibrational spectroscopy is a new approach that can identify novel biomarkers for early detection of HFpEF.

Keyphrases

density functional theory
single molecule
high resolution
molecular dynamics simulations
raman spectroscopy
energy transfer
solid state
heart failure
gene expression
left ventricular
genome wide
atrial fibrillation
molecular dynamics
drug discovery
fluorescent probe
mass spectrometry
simultaneous determination