Survival and dementia in GBA-associated Parkinson's disease: The mutation matters.
Roberto CiliaSara TunesiGiorgio MarottaEmanuele CeredaChiara SiriSilvana TeseiAnna L ZecchinelliMargherita CanesiClaudio B MarianiNicoletta MeucciGiorgio SacilottoMichela ZiniMichela BarichellaCorrado MagnaniStefano DugaRosanna AsseltaGiulia SoldàAgostino SeresiniManuela SeiaGianni PezzoliStefano GoldwurmPublished in: Annals of neurology (2016)
Survival is reduced in GBA carriers compared to noncarriers; this seems to be partially independent from the increased risk for early dementia. The risk for dementia is strongly modulated by type of mutation. In the clinical continuum between PD and DLB, patients with GBA mutations seem to localize midway, with carriers of severe mutations closer to DLB than to idiopathic PD. Ann Neurol 2016;80:662-673.