Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis.
Nora PashayanStephen W DuffyDavid E NealFreddie C HamdyJenny L DonovanRichard M MartinPatricia HarringtonSara BenllochAli Amin Al OlamaMitul ShahZsofia Kote-JaraiDouglas F EastonRosalind EelesPaul David Peter PharoahPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2015)
Targeting screening to men at higher polygenic risk could reduce the problem of overdiagnosis and lead to a better benefit-to-harm balance in screening for prostate cancer.