The Effect of miR-505-5p on Inhibition of Serum Uromodulin Ameliorates Myocardial Inflammation and Apoptosis Induced by Ischemia-Reperfusion.

Dongsheng HeJun HuYuhai LuWeikun JiaMinxue WeiXiaofei Zeng Hong Wang

Published in: Oxidative medicine and cellular longevity (2022)

miR-505-5p can improve I/R-mediated myocardial apoptosis and inflammation by targeting sUmod. In this study, miR-505-5p is related to MIRI pathogenesis, which provides the new possible targeted therapy in patients with MIRI.

Keyphrases

oxidative stress
endoplasmic reticulum stress
cell cycle arrest
left ventricular
cell death
heart failure
mouse model
cell proliferation