Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer.

Hiroko KimuraKei MizunoMasaki ShiotaShintaro NaritaNaoki TeradaNaohiro FujimotoKeiji OguraShotaro HatanoYusuke IwasakiNozomi HakozakiSatoshi IshitoyaTakayuki SumiyoshiTakayuki GotoTakashi KobayashiHidewaki NakagawaToshiyuki KamotoMasatoshi EtoTomonori HabuchiOsamu OgawaYukihide MomozawaShusuke Akamatsu

Published in: British journal of cancer (2022)

Germline variants in BRCA1, BRCA2, PALB2 or ATM are independent prognostic factors of the short duration of response to hormonal therapy in advanced PCa.

Keyphrases

prognostic factors
prostate cancer
dna repair
breast cancer risk
dna damage
copy number
polycystic ovary syndrome
dna damage response
radical prostatectomy
genome wide
metabolic syndrome
gene expression
insulin resistance
dna methylation
transcription factor
skeletal muscle
bone marrow