MSC-Derived Extracellular Vesicles to Heal Diabetic Wounds: a Systematic Review and Meta-Analysis of Preclinical Animal Studies.

Adrian J M BaileyHeidi LiAidan M KirkhamAlvin TieuHarinad B MagantiRisa ShorrDean A FergussonManoj M LaluHeidi ElomazzenDavid S Allan

Published in: Stem cell reviews and reports (2021)

PROSPERO #CRD42020199327 [248]. Forest plot demonstrating increased wound closure rates of diabetic wounds receiving genetically modified MSC-EVs that were enriched for specific RNAs. DFO = deferoxamine. Control groups were inactive (no treatment or saline) except for 3 studies which used hydrogels without MSC-EVs as control (Li M 2016; Shi 2017; Tao 2016).

Keyphrases

wound healing
case control
type diabetes
climate change
drug delivery
stem cells
drug release
mesenchymal stem cells
extracellular matrix
replacement therapy
smoking cessation