Multidrug-resistant Mycobacterium tuberculosis: a report of cosmopolitan microbial migration and an analysis of best management practices.
Oana JoeanThea ThieleKatharina SchützNicolaus SchwerkLudwig SedlacekBarbara KalsdorfUlrich BaumannMatthias StollPublished in: BMC infectious diseases (2020)
Human migration plays an important role for the global spread of MDR-TB in low incidence countries. Early case detection and adequate treatment are key to prevention of outbreaks. Especially language barriers and complex migration routes make genotyping of TB-strains a crucial tool to identify cases clusters, the potential index patient and transmission dynamics. We are fortunate enough to experience times in which new TB-antibiotics were made available and in which molecular assays revolutionized TB-diagnostics. We need to take advantage of that and develop personalized therapies for patients suffering from drug resistant TB.
Keyphrases
- mycobacterium tuberculosis
- multidrug resistant
- drug resistant
- acinetobacter baumannii
- pulmonary tuberculosis
- gram negative
- end stage renal disease
- klebsiella pneumoniae
- escherichia coli
- newly diagnosed
- endothelial cells
- healthcare
- primary care
- chronic kidney disease
- peritoneal dialysis
- risk factors
- autism spectrum disorder
- prognostic factors
- climate change
- genome wide
- case report
- gene expression
- risk assessment
- genetic diversity
- loop mediated isothermal amplification
- smoking cessation