A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus.
Zutao YuMengting AiSoumen K SamantaFumitaka HashiyaJunichi TaniguchiSefan AsamitsuShuji IkedaKaori HashiyaToshikazu BandoGanesh N PandianLyle D IsaacsHiroshi SugiyamaPublished in: Chemical communications (Cambridge, England) (2020)
We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host-guest modules. This new type of molecule termed ePIP-HoGu not only mimics the operation of transcription factors as a pair but also recruits the epigenetic modifier to a particular DNA locus.