Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties.

Katja Maria BendtsenLouise GrenVilhelm Berg MalmborgPravesh Chandra ShuklaMartin TunérYona J EssigAnnette M KraisPer Axel ClausenTrine BerthingKatrin LoeschnerNicklas Raun JacobsenHenrik WolffJoakim PagelsUlla Birgitte Vogel

Published in: Particle and fibre toxicology (2020)

We studied diesel exhaust particles designed to differ in physicochemical properties. Our study highlights specific surface area, elemental carbon content, PAHs and ROS-generating potential as physicochemical predictors of diesel particle toxicity.

Keyphrases

particulate matter
oxidative stress
air pollution
human health
cell death
dna damage
high fat diet induced
reactive oxygen species
type diabetes
risk assessment
metabolic syndrome
oxide nanoparticles
insulin resistance
drinking water