mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis.
Wang MinLingfeng QinHaifeng ZhangFrancesc LopezNing JiangYeaji KimVarsha K MohanMinhong SuKatie N MurrayJaime GrutzendlerJenny Huanjiao ZhouPublished in: Circulation research (2024)
CCM3 is critical for maintaining blood-brain barrier integrity and CCM3 loss-induced mTORC1 signaling in brain EPCs initiates and facilitates CCM pathogenesis.