Identification and validation of circulating miRNAs as potential new biomarkers for severe liver disease in patients with leptospirosis.
Natthaya ChuaypenUmaporn LimothaiPattapon KunadirekPornchai KaewsapsakPatipark KueanjindaNattachai SrisawatPisit TangkijvanichPublished in: PloS one (2021)
Our data indicated that miRNA expression profiles were significantly differentiated between the icteric and anicteric groups. Serum miR-601 and miR-630 at presentation could potentially serve as promising biomarkers for predicting subsequent acute liver failure and overall survival in patients with leptospirosis.