A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury.

Chuanhao LiuLin ZhouYing ZhengHuizi ManZhiwei YeXinfu ZhangLijuan XieYi Xiao

Published in: Chemical communications (Cambridge, England) (2022)

We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor (GA-Vis) was developed. With the aid of GA-Vis, the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury.

Keyphrases

pet ct
early stage
endoplasmic reticulum
alcohol consumption
induced apoptosis
cancer therapy
high resolution
current status
lymph node