Radiation dose escalation can improve local disease control and survival among esophageal cancer patients with large primary tumor volume receiving definitive chemoradiotherapy.
Forn-Chia LinWei-Lun ChangNai-Jung ChiangMeng-Ying LinTa-Jung ChungTzu-Hui PaoWu-Wei LaiYau-Lin TsengYi-Ting YenBor-Shyang SheuPublished in: PloS one (2020)
Large primary tumor volume correlates with poor local control and overall survival in ESCC treated with definitive CCRT. Radiation dose > 60 gray can improve the outcomes in patients with large primary tumor. Further prospective dose escalation trials are warranted.