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Vaccination with a chikungunya virus-like particle vaccine exacerbates disease in aged mice.

Maria T ArévaloYing HuangCheryl A JonesTed M Ross
Published in: PLoS neglected tropical diseases (2019)
Unadjuvanted CHIK VLP vaccination elicits immune responses that protect 100% of adult mice against CHIKV infection. However, an improved vaccine/adjuvant combination is still necessary to enhance the protective immunity against CHIKV in the aged.
Keyphrases
  • immune response
  • high fat diet induced
  • zika virus
  • early stage
  • dendritic cells
  • type diabetes
  • toll like receptor
  • aedes aegypti
  • insulin resistance
  • metabolic syndrome
  • young adults
  • adipose tissue
  • inflammatory response