Vaccination with a chikungunya virus-like particle vaccine exacerbates disease in aged mice.
Maria T ArévaloYing HuangCheryl A JonesTed M RossPublished in: PLoS neglected tropical diseases (2019)
Unadjuvanted CHIK VLP vaccination elicits immune responses that protect 100% of adult mice against CHIKV infection. However, an improved vaccine/adjuvant combination is still necessary to enhance the protective immunity against CHIKV in the aged.