Vaccination with a chikungunya virus-like particle vaccine exacerbates disease in aged mice.

Maria T ArévaloYing HuangCheryl A JonesTed M Ross

Published in: PLoS neglected tropical diseases (2019)

Unadjuvanted CHIK VLP vaccination elicits immune responses that protect 100% of adult mice against CHIKV infection. However, an improved vaccine/adjuvant combination is still necessary to enhance the protective immunity against CHIKV in the aged.

Keyphrases

immune response
high fat diet induced
zika virus
early stage
dendritic cells
type diabetes
toll like receptor
aedes aegypti
insulin resistance
metabolic syndrome
young adults
adipose tissue
inflammatory response