TLR8 agonist partially improves IFN-γ deficiency of NK cells in chronic hepatitis B through the synergy of monocytes.

Xiulan AoQiaorong GanXuan HuangDongpeng BaoXuwei WuQiuxiang LinAifang LinYating DingLingxia WangYanping ChenZuxiong Huang

Published in: Alimentary pharmacology & therapeutics (2022)

In patients with CHB, targeting TLR8 partially rescues the IFN-γ insufficiency in NK cells. However, NK cells show an inhibitory response to TLR8 agonist stimulation. TLR8 agonist combined with NA may enhance the antiviral effect of NK cells.

Keyphrases

nk cells
immune response
toll like receptor
inflammatory response
dendritic cells
nuclear factor
hepatitis b virus
mouse model
peripheral blood
smoking cessation