Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin.
Felix NagelAnne SusemihlNorman GeistKevin MöhlisGottfried J PalmMichael LammersMihaela DelceaPublished in: Journal of inflammation research (2022)
We provide a structure of TRY2, which is the predominant trypsin isoform in chronic pancreatitis and pancreatic cancer. A proposed autoinhibition mode was confirmed and the structural basis of the autoproteolytic failsafe mechanism elucidated.
Keyphrases