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An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo.

Celia LujanEleanor Jane TylerSimone EckerAmy Philomena WebsterEleanor Rachel SteadVictoria Eugenia Martinez-MiguelDeborah MilliganJames Charles GarbeMartha Ruskin StampferStephan BeckRobert LoweCleo Lucinda BishopIvana Bjedov
Published in: Genome medicine (2024)
Our method expands the scope of CpG methylation profiling to accurately and rapidly detecting anti-ageing potential of drugs using human cells in vitro, and in vivo, providing a novel accelerated discovery platform to test sought after anti-ageing compounds and geroprotectors.
Keyphrases
  • high throughput
  • small molecule
  • dna methylation
  • single cell
  • gene expression
  • genome wide
  • risk assessment