VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes.
Ligia Simoes Braga BoisserandJean BouchartLuiz Henrique Medeiros GeraldoSeyoung LeeBasavaraju G SanganahalliMaxime ParentShenqi ZhangYuechuan XueMario SkaricaJustine GueganMingfeng LiXiodan LiuMathilde PouletMichael AskanaseArtem OsherovMyriam SpajerMarie-Renee El KamouhAnne EichmannKari AlitaloJiangbing ZhouNenad SestanLauren H SansingHelene BenvenisteFahmeed HyderJean-Leon ThomasPublished in: bioRxiv : the preprint server for biology (2023)
Intrathecal delivery of VEGF-C increases the lymphatic drainage of brain-derived fluids confers neuroprotection, and improves neurological outcomes after ischemic stroke.