The association of elevated maternal genetic risk scores for hypertension, type 2 diabetes and obesity and having a child with a congenital heart defect.

Michelle A KaplinskiDeanne TaylorLaura E MitchellDorothy A HammondElizabeth GoldmuntzA J Agopiannull null

Published in: PloS one (2019)

Our results support a link between maternal genetic risk for hypertension/T2D and CTDs in their offspring. These associations might be independent of maternal phenotype at conception.

Keyphrases

type diabetes
birth weight
blood pressure
pregnancy outcomes
insulin resistance
weight gain
genome wide
metabolic syndrome
mental health
high fat diet
cardiovascular disease
pregnant women
body mass index
gestational age
skeletal muscle
high fat diet induced
soft tissue