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[3+2] Cascade Ring-Closing/Ring-Opening Strategy: Access to N -Indene-Tethered Amino Alcohols.

Imtiaj MondalShantonu RoyKoushik NaskarSudip KarmakarMoumita ChowdhuryIndubhusan Deb
Published in: Organic letters (2023)
An unprecedented atom-economic redox neutral regioselective Rh(III)-catalyzed cascade [3+2] annulation of 2-aryl oxazoline with α,β-unsaturated nitro olefins has been accomplished, furnishing a novel set of nitro-functionalized indene-tethered amino alcohols through a synergistic ring-closing/ring-opening strategy via the formation of two new C-C bonds and the regioselective cleavage of the C2-O bond of oxazoline under silver free mild reaction conditions with a broad substrate scope.
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